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Quantification of Proteolytic Pathways in MCF7 Breast Cancer Cells

  • 2/11/2019 6:30:00 AM
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Quantification of Proteolytic Pathways in MCF7 Breast Cancer Cells

Jessica Cardin, PhD

Protein degradation is a main component of the body to enable proper function and tissue maintenance. Certain types of cancer have demonstrated to have an enhanced ability to degrade malformed proteins through intracellular systems. The ability to break these proteins down has the potential to protect cancerous cells and allow them to proliferate. Specific degradation pathways have exhibited the capacity to alter the cell cycle, leading to tumors to increase in aggressiveness and drug resistance. Thus a method that is easily employed to accurately quantify the rates of this flux is of utmost importance. This research is important to conduct as it will be the first study to be able to precisely enumerate protein degradation across all the protein pathways. Being able to understand how quickly or slowly the protein breakdown is occurring, and through which cellular mechanism will be invaluable for medical professionals to help produce potential therapeutic targets to combat these terrible conditions.

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